A Comprehensive Review on Tri-Component Chitosan/Hyaluronic Acid/Antibiotic Composite Nanofibers for Advanced Wound Healing in Elderly Patients: Design, Fabrication, and Clinical Applications

Wound Healing

Authors

  • Elnaz Momeni Nasab Department of biomedical engineering, ST.B., Islamic Azad University, Tehran, Iran
  • Zahra Pakdaman Department of biomedical engineering, ST.B., Islamic Azad University, Tehran, Iran
  • Fatemeh Zarehzadeh Dental Islamic Azad University, Tehran Dental Branch,Iran

DOI:

https://doi.org/10.5281/zenodo.16018734

Keywords:

Antibacterial nanofibers, Chitosan-HA dressings, Elderly wound healing, Drug-loaded scaffolds, Pressure ulcer therapy

Abstract

The increasing prevalence of chronic wounds among aging populations necessitates innovative therapeutic approaches. This review systematically examines the development of electrospun tri-component nanofibers incorporating chitosan (CS), hyaluronic acid (HA), and antibiotics for pressure ulcer management in elderly patients. Building upon recent advancements in nanofiber technology and incorporating findings from key studies (Abdi et al., 2024; Branch & Branch, 2024; Mirani et al., 2021, 2022; Mahmoud et al., 2023), we analyze the scientific rationale, material properties, fabrication techniques, and clinical potential of these advanced wound dressings. The review highlights the synergistic effects of CS's antimicrobial properties, HA's tissue-regenerative capabilities, and controlled antibiotic release, while addressing current challenges in clinical translation and proposing future research directions.

References

[1]Abdi, H., Mirani, A., & Jafari, R. (2024). Quantitative assessment of traumatic brain injury risk in diverse age groups of females: Insights from computational biomechanics. Heliyon, 10(10), e31542. https://doi.org/10.1016/j.heliyon.2024.e31542

[2] Branch, G., & Branch, S. T. (2024). Electrospun ZnO and GSH co-loaded PU/CS nanofibrous films as potential antibacterial wound dressings. World Journal of Nano Science and Engineering, 16, 2450028. https://doi.org/10.1142/S0219581X24500285

[3] Mirani, A., Maleknia, L., & Amirabadi, A. (2022). Preparation of Bio-Sensor with Hybrid Nanofibers of Chitosan/Functional Carbon Nanotubes for the Sensing of Nicotine. Journal of Color Science and Technology, 15(4), 271-286. https://doi.org/10.30495/jcst.2022.1945558.1032

[4]Mirani, A., Maleknia, L., & Amirabadi, A. (2021). Nicotine Degradation Detection by Marine Plants Using Hybrid Modified Electrode Made of Chitosan Nanofibers and Functionalized Carbon Nanotubes. Journal of Marine Medicine, 3(2), 75-82. https://doi.org/10.30495/jmm.2021.1940322.1007

[5]Mahmoud, Z. H., Hussein, U. A. R., Aljbory, N., Alnajar, M. J., Maleknia, L., & Mirani, A. (2023). Development of Vitex-derived polymer nanofibers using electrochemical sensors for the treatment of polycystic ovarian syndrome in rats as an animal model. Biosensors and Bioelectronics: X, 22, 100570. https://doi.org/10.1016/j.biosx.2023.100570

Downloads

Published

2025-07-15 — Updated on 2025-07-16

Versions

How to Cite

Momeni Nasab, E., Pakdaman, Z., & Zarehzadeh, F. (2025). A Comprehensive Review on Tri-Component Chitosan/Hyaluronic Acid/Antibiotic Composite Nanofibers for Advanced Wound Healing in Elderly Patients: Design, Fabrication, and Clinical Applications: Wound Healing. MEDICO&ENGINEERING FUTURE, 2(1), 23–29. https://doi.org/10.5281/zenodo.16018734 (Original work published July 15, 2025)

Issue

Vol. 2 No. 1 (2025): Summer2025

Section

Review Articles

Categories

License

Copyright (c) 2025 MEDICO&ENGINEERING FUTURE

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.